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Obesity |
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| Obesity is a condition in which the natural energy reserve, stored in the fatty tissue of humans exceeds healthy limits. |
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| Morbid obesity |
Morbid obesity, also known as clinically severe obesity, is an abnormal obesity defined as the condition of having body weight over 100 Ibs over an ideal body weight or having a body mass index (BMI) of 40 or higher. A BMI of 35.0 or higher in the presence of at least one other significant comorbidity is also classified by some bodies as morbid obesity. In recent years, morbid obesity has also become present in both children and teenagers due to the childhood obesity epidemic. As evident in western culture, children have began to become more overweight than their parents and grandparents were when they were children, partially due to technology such as computers and television, as well as the possibly daily intake of fatty meals. |
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| Classification |
In practical settings, obesity is typically evaluated in absolute terms by measuring BMI (body mass index), but also in terms of its distribution through waist circumference or waist-hip circumference ratio measurements.In addition, the presence of obesity needs to be regarded in the context of other risk factors and comorbidities (other medical conditions that could influence risk of complications). |
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| BMI |
It is calculated by dividing the subject's weight by the square of his/her height.
Metric: BMI = kg / m2
Where kg is the subject's weight in kilograms and m is the subject's height in metres.
The most commonly used definitions, established by the WHO in 1997 and published in 2000, provide the following values: |
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A BMI less than 18.5 is underweight |
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A BMI of 18.5–24.9 is normal weight |
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A BMI of 25.0–29.9 is overweight |
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A BMI of 30.0–39.9 is obese |
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A BMI of 40.0 or higher is severely (or morbidly) obese |
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A BMI of 35.0 or higher in the presence of at least one other significant comorbidity is also classified by some bodies as morbid obesity. |
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Calorie Requirement for Age and lifestyle (Nutritions Tools)
This utility helps in calculating your required calories depending on your age group and life style.
Daily Calorie Requirement
A few interesting facts :
- It is recommended that 50 to 60% of your calories comes from carbohydrates, 20% from proteins and 15 to 20% from fat is recommended.
- Due to the biological changes in the body, adolescents' caloric requirements are high.
- Expectant mothers require 300 calories extra per day.
- Lactating mothers initially require 550 cals/d and later require 400 cals/d.
- Calorie requirements of an individual can be calculated with the Harris-Benedict formula.
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In a clinical setting, physicians take into account race, ethnicity, lean mass (muscularity), age, sex, and other factors which can affect the interpretation of BMI. BMI overestimates body fat in persons who are very muscular, and it can underestimate body fat in persons who have lost body mass (e.g. many elderly). Mild obesity as defined by BMI alone is not a cardiac risk factor, and hence BMI cannot be used as a sole clinical and epidemiological predictor of cardiovascular health. |
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| Waist circumference |
BMI does not take into account differing ratios of adipose to lean tissue; nor does it distinguish between differing forms of adiposity, some of which may correlate more closely with cardiovascular risk. Increasing understanding of the biology of different forms of adipose tissue has shown that visceral fat or central obesity (male-type or apple-type obesity, also known as "belly fat") has a much stronger correlation, particularly with cardiovascular disease, than the BMI alone.
The absolute waist circumference (>102 cm in men and >88 cm in women) or waist-hip ratio (>0.9 for men and >0.85 for women) are both used as measures of central obesity. |
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| Body fat measurement |
An alternative way to determine obesity is to assess percent body fat. Doctors and scientists generally agree that men with more than 25% body fat and women with more than 30% body fat are obese. However, it is difficult to measure body fat precisely. The most accepted method has been to weigh a person underwater, but underwater weighing is a procedure limited to laboratories with special equipment. Two simpler methods for measuring body fat are the skinfold test, in which a pinch of skin is precisely measured to determine the thickness of the subcutaneous fat layer; or bioelectrical impedance analysis, usually only carried out at specialist clinics. Their routine use is discouraged.
Other measurements of body fat include computed tomography (CT/CAT scan), magnetic resonance imaging (MRI/NMR), and dual energy X-ray absorptiometry (DXA). |
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| Risk factors and comorbidities |
The presence of risk factors and diseases associated with obesity are also used to establish a clinical diagnosis. Coronary heart disease, type 2 diabetes, and sleep apnea are possible life-threatening risk factors that would indicate clinical treatment of obesity. Smoking, hypertension, age and family history are other risk factors that may indicate treatment. |
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| Effects on health |
A large number of medical conditions have been associated with obesity. Health consequences are categorised as being the result of either increased fat mass (osteoarthritis, obstructive sleep apnea, social stigma) or increased number of fat cells (diabetes, cancer, cardiovascular disease, non-alcoholic fatty liver disease).Mortality is increased in obesity, with a BMI of over 32 being associated with a doubled risk of death. There are alterations in the body's response to insulin (insulin resistance), a proinflammatory state and an increased tendency to thrombosis (prothrombotic state).
Disease associations may be dependent or independent of the distribution of adipose tissue. Central obesity (male-type or waist-predominant obesity, characterised by a high waist-hip ratio), is an important risk factor for the metabolic syndrome, the clustering of a number of diseases and risk factors that heavily predispose for cardiovascular disease. These are diabetes mellitus type 2, high blood pressure, high blood cholesterol, and triglyceride levels (combined hyperlipidemia).
Apart from the metabolic syndrome, obesity is also correlated with a variety of other complications. For some of these complaints, it has not been clearly established to what extent they are caused directly by obesity itself, or have some other cause (such as limited exercise) that causes obesity as well. |
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Cardiovascular: congestive heart failure, enlarged heart and its associated arrhythmias and dizziness, varicose veins, and pulmonary embolism |
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Endocrine: polycystic ovarian syndrome (PCOS), menstrual disorders, and infertility |
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Gastrointestinal: gastroesophageal reflux disease (GERD), fatty liver disease, cholelithiasis (gallstones), hernia, and colorectal cancer |
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Renal and genitourinary: erectile dysfunction, urinary incontinence, chronic renal failure, hypogonadism (male), breast cancer (female), uterine cancer (female), stillbirth |
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Integument (skin and appendages): stretch marks, acanthosis nigricans, lymphedema, cellulitis, carbuncles, intertrigo |
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Musculoskeletal: hyperuricemia (which predisposes to gout), immobility, osteoarthritis, low back pain |
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Neurologic: stroke, meralgia paresthetica, headache, carpal tunnel syndrome, dementia, idiopathic intracranial hypertension |
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Respiratory: obstructive sleep apnea, obesity hypoventilation syndrome, asthma |
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Psychological: Depression, low self esteem, body dysmorphic disorder, social stigmatization |
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While being severely obese has many health ramifications, those who are somewhat overweight face little increased mortality or morbidity. Osteoporosis is known to occur less in slightly overweight people. |
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| Causes and mechanisms |
| Lifestyle |
Most researchers have concluded that the combination of an excessive nutrient intake and a sedentary lifestyle are the main cause for the rapid acceleration of obesity. Obesity caused specifically by overeating is called exogenous obesity.
(1) increased distribution of ethnic and age groups that tend to be heavier, (2) pregnancy at a later age, (3) intrauterine and intergenerational effects, (4) positive natural selection of people with a higher BMI. |
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| Medical illness |
Medical illnesses that increase obesity risk include several rare congenital syndromes (listed above), hypothyroidism, Cushing's syndrome, growth hormone deficiency.. Certain medications (e.g. steroids, atypical antipsychotics, some fertility medication) may cause weight gain.
Mental illnesses may also increase obesity risk, specifically some eating disorders. |
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| Neurobiological mechanisms |
Since leptin's discovery, ghrelin, orexin, PYY 3-36, cholecystokinin, adiponectin, and many other mediators have been studied. The adipokines are mediators produced by adipose tissue; their action is thought to modify many obesity-related diseases.
Leptin and ghrelin are considered to be complementary in their influence on appetite, with ghrelin produced by the stomach modulating short-term appetitive control (i.e. to eat when the stomach is empty and to stop when the stomach is stretched). Leptin is produced by adipose tissue to signal fat storage reserves in the body, and mediates long-term appetitive controls (i.e. to eat more when fat storages are low and less when fat storages are high). Although administration of leptin may be effective in a small subset of obese individuals who are leptin deficient, many more obese individuals are thought to be leptin resistant. This resistance is thought to explain in part why administration of leptin has not been shown to be effective in suppressing appetite in most obese subjects.
While leptin and ghrelin are produced peripherally, they control appetite through their actions on the central nervous system. In particular, they and other appetite-related hormones act on the hypothalamus, a region of the brain central to the regulation of food intake and energy expenditure. Thus a deficiency in leptin signaling, either via leptin deficiency or leptin resistance, leads to overfeeding and may account for some genetic and acquired forms of obesity. |
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| Treatment |
The main treatment for obesity is to reduce body fat by eating fewer calories and exercising more. Diet and exercise programs produce an average weight loss of approximately 8% of total body mass (excluding program drop-outs). Not all dieters are satisfied with these results, but a loss of as little as 5% of body mass can create large health benefits.
Much more difficult than reducing body fat is keeping it off. Eighty to ninety-five percent of those who lose 10% or more of their body mass by dieting regain all that weight back within two to five years. Therefore, keeping weight off generally requires making exercise and eating right a permanent part of a person's lifestyle. |
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| Clinical protocols |
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People with a BMI of over 30 should be counseled on diet, exercise and other relevant behavioral interventions, and set a realistic goal for weight loss. |
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If these goals are not achieved, pharmacotherapy can be offered. The patient needs to be informed of the possibility of side-effects and the unavailability of long-term safety and efficacy data. |
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In patients with BMI > 40 who fail to achieve their weight loss goals (with or without medication) and who develop obesity-related complications, referral for bariatric surgery may be indicated. The patient needs to be aware of the potential complications. |
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| Dieting |
| Anti-Obesity Drugs |
Medication most commonly prescribed for diet/exercise-resistant obesity is orlistat (which reduces intestinal fat absorption by inhibiting pancreatic lipase) and sibutramine (an anorectic). Weight loss with these drugs is modest, and over the longer term average weight loss on orlistat is 2.9 kg, sibutramine 4.2 kg and rimonabant 4.7 kg. Orlistat and rimonabant lead to a reduced incidence of diabetes, and all drugs have some effect on lipoproteins (different forms of cholesterol). There is little data, however, on longer-term complications of obesity such as heart attacks. All drugs have side-effects and potential contraindications. It is common for weight loss drugs to be tried for a period of time (e.g. 3 months), and to discontinue them or change to another agent if no benefit is achieved, such as weight loss less than 5% the total body weight.
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| Bariatric surgery |
Two large studies have demonstrated a mortality benefit from bariatric surgery. A marked decrease in the risk of diabetes mellitus, cardiovascular disease and cancer has been found. Weight loss was most marked in the first few months after surgery, but the benefit was sustained in the longer term. |
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| Sleeve gastrectomy |
Sleeve gastrectomy is a surgical weight-loss procedure in which the stomach is reduced to about 35% of its original size, by surgical removal of a large portion of the stomach, following the major curve. The open edges are then attached together (often with surgical staples) to form a sleeve or tube with a banana shape. The procedure permanently reduces the size of the stomach. The procedure is performed laparoscopically and is not reversible. |
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| Procedure |
Sleeve gastrectomy is usually performed on extremely obese patients, where the risk of performing a gastric bypass or duodenal switch procedure may be too large. A two-stage procedure is performed: the first is a sleeve gastrectomy, and the second is a conversion into a gastric bypass or duodenal switch. Patients usually lose a large quantity of their excess weight after the first sleeve gastrectomy procedure alone, but if weight loss ceases the second step is performed. |
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| Complications |
Like any surgical operation, sleeve gastrectomy has possible complications, such as leakage, dilation of the sleeve (which allows for more food intake) and other usual complications associated with bariatric surgery, though the risks are known to be much lower than in RNY gastric bypass and duodenal switch. |
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